Nicolas,
All my other watches are 44mm or more and this is actually my "smallest" watch! (My largest is the 57.5mm Zenith Type 20, by the way!)
So do take what I say with a pinch of salt, cos I am clearly used to big watches.
This watch is absolutely comfortable. And the glide lock micro adjustment makes wearing this a dream. I think my wrists expand during different times of the day and suddenly a watch which was tight will start feeling a bit loose.
But the glide lock has ensured the adjustments are perfect.
I don't think wearing comfort should be an issue.
The watch is a bit thick / high if you are not used to big watches, but size wise quite wearable.