Off-center dials were odd to me as well until I started looking at early Breguet designs (by A.L.Breguet himself) and you start to see that off-center minute/hour dials are very much a part of the original Breguet aesthetic. The intersecting circle of the tourbillon adds interest and wouldn't be out of place to A.L.Breguet's eye. It's not at all the same as Patek being unable to cram in everything on a grand complication and having to deviate from their intended look as a result--a flaw which is then fixed in a subsequent iteration. That's not to say that one must like the Breguet, just that it's a whole different kettle of enamel. Maybe a good question is whether the asymmetry looks better with the guilloche dial or the enamel?