And a lovely watch for sure!!!
As per the hands, i´m not an overly huge fan of unauthorized modifications.
Sure 22" wheels can do well on a Rolls-Royce, but for most of the time to me it seems there´s a reason they don´t come with these straight from the factory... 
Aside service/warranty issues (unauthorized modifications terminate all warranties that may apply), i think the Pisa Dato already is special. It just don´t need the blue hands and the heavy contrast is not my preferred choice. It´s certainly a very legible configuration this way, but then i quite like the luminous hands.
It´s still a very nice watch
Cheers,
Peter